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Monday, August 3, 2020 | History

2 edition of Oxygen-enhanced magnetic resonance imaging of mice lungs. found in the catalog.

Oxygen-enhanced magnetic resonance imaging of mice lungs.

Kristina N. Watt

Oxygen-enhanced magnetic resonance imaging of mice lungs.

by Kristina N. Watt

  • 106 Want to read
  • 19 Currently reading

Published .
Written in English


About the Edition

Pulmonary magnetic resonance (MR) imaging provides valuable information about lung anatomy and perfusion and ventilation physiology. Oxygen-enhanced MR imaging visualizes the effect of ventilation using inhaled molecular oxygen as a T1-shortening contrast agent. The technique is challenged, however, by low proton density of lung tissue and cardiopulmonary physiology that result in reduced MR signal and increased motion artifacts.With the growing interest in mouse models of respiratory disease, application of human pulmonary MR techniques to mice is highly desirable. The purpose of this work was to develop oxygen-enhanced MR imaging as a non-invasive tool to examine ventilation in free-breathing mice. An optimized cardiac-triggered, respiratory-gated fast spin echo sequence was developed for oxygen-enhanced MR and successfully demonstrated in normal mice. Ventilation was visualized as significant signal enhancement in the lung parenchyma with pure oxygen inhalation. This sequence shows potential for application to studies of abnormal ventilation in models of pulmonary disease.

The Physical Object
Pagination68 leaves.
Number of Pages68
ID Numbers
Open LibraryOL21218870M
ISBN 109780494273579

  Oxygen‐enhanced 1 H MRI. Difficulties in imaging the lung with proton MRI led to a search for alternatives. Oxygen‐enhanced proton MRI has been studied as a means of measuring ventilation 47 The technique uses fast imaging sequences (such as single‐shot fast‐spin echo, with an inversion recovery pre‐pulse) to introduce some T1 Cited by: A magnetic resonance imaging method is presented that allows for the simultaneous assessment of oxygen delivery, oxygen uptake, and parenchymal density. The technique is applied to a mouse model of porcine pancreatic elastase (PPE) induced lung emphysema in order to investigate how structural changes affect lung by: 4.

The use of aerosolized gadopentetate dimeglumine to define regional lung ventilation and of intravenously administered polylysine-(gadopentetate dimeglumine)40 to assess regional lung Cited by:   To determine if 1H magnetic resonance images of the human lung and airways can be obtained in both single breath-hold and gated breathing imaging studies with adequate signal level and image contrast to extract regional lung functional information with oxygen as a contrast agent.

Overview of Magnetic Resonance Imaging. To appreciate the opportunities and limitations of MRM, a basic introduction to the fundamentals of magnetic resonance imaging is useful (Bushberg ; Haacke ; Hornak ).First, it is important to understand the source of signal in MRI, which originates from the tiny nuclear magnetic moments of the constituent atoms and molecules that make Cited by: At oxygen delivery, oxygen uptake, and lung density were quantified from T1 and proton-density measurements obtained via oxygen-enhanced magnetic resonance imaging (OE-MRI) using an.


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Oxygen-enhanced magnetic resonance imaging of mice lungs by Kristina N. Watt Download PDF EPUB FB2

In book. Oxygen-enhanced Proton Magnetic Resonance Imaging of the Human Lung Eberhard D, Pracht, Johannes F,T, Arnold, Nicole Seiberlich, Markus Kotas, Michael Flentje, and Peter M, Jakob Introduction One of the major goals in pulmonary diagnostics is to detect pathologies in the lung using modern imaging : Eberhard D.

Pracht, Johannes F.T. Arnold, Nicole Seiberlich, Markus Kotas, Michael Flentje, Peter M. Conclusion. Using slice-selective RF pulses, parallel imaging, and combined respiratory and ECG triggering, oxygen-enhanced lung MRI with the acquisition of six slices and 80 repetitions can be performed in 8 to 13 min depending on the respiratory frequency of the examined by: 2.

Effective respiratory and cardiac synchronization can be achieved in oxygen-enhanced magnetic resonance imaging of the lung, using a pneumotachograph for real-time targeting of end-expiration. lung. Proton MR imaging of the lung, including oxygen-en-hanced MR, is challenged by the unique morphology and physiology of the lung.

The low proton density of the inflated lung tissue, multiple air-tissue interfaces of the alveoli, and movement of the chest all result in poor image quality due to reduced MR signal, large magnetic suscep. This phenomenon was observed even before Gd-chelate agents came into use, therefore, utilization of molecular oxygen as a contrast agent for the lungs might be quite natural.

Oxygen-enhanced magnetic resonance (MR) imaging of the lungs has provided a unique method to demonstrate regional ventilation-related by: Unlike any other organ, imaging of lungs with magnetic resonance faces unique challenges owing to the complex microstructure and presence of gas-tissue interfaces.

With the evolution of faster and Cited by: 3. To prospectively estimate the feasibility and reproducibility of dynamic oxygen-enhanced magnetic resonance imaging (OE-MRI) in the assessment of regional oxygen delivery, uptake and washout in asthmatic by:   Oxygen-Enhanced Magnetic Resonance Imaging.

Tumors showed considerable heterogeneity in terms of baseline R 2 * and R 1, as well as responses to oxygen challenge (semi quantitative BOLD and TOLD; quantitative ΔR 2 * and ΔR 1; Fig.

Mean R 1 for individual tumors ranged from to s −1 with a population mean ± s. Oxygen-enhanced magnetic resonance imaging Anesthetized rats were provided with a warming pad to maintain body temperature, placed in a T MR scanner and physiological parameters recorded using an MR-compatible monitoring and gating by:   Oxygen-enhanced magnetic resonance imaging (MRI) has been proposed as a useful tool for assessing regional morphological and functional changes in chronic obstructive pulmonary disease (COPD) but there is limited information comparing oxygen-enhanced MRI and quantitative computed tomography (CT).

What This Study Adds to the FieldCited by: Lung magnetic resonance imaging – an update. human lung using oxygen-enhanced magnetic resonance. imaging. Nature Med ;–9. Mai VM, Chen Q, Bankier AA, Edelman RR. The current work is a continuation of a new MRI technique that was proposed for the non-invasive assessment of regional lung ventilation using inhaled molecular oxygen as aT 1 contrast agent.

Several improvements of this technique are described in this work. The signal-to-noise ratio in the ventilation-scan images was optimized using a centrically reordered single-shot RARE sequence with Cited by: This chapter presents the most important developments in 1H magnetic resonance (1H MR) lung imaging using oxygen as contrast agent and highlights the concept and theory of oxygen-enhanced imaging.

Purpose: A magnetic resonance imaging method is presented that allows for the simultaneous assessment of oxygen delivery, oxygen uptake, and parenchymal density. The technique is applied to a mouse Author: Olaf Dietrich. Oxygen-Enhanced MR Ventilation Imaging of the Lung JulyVOLUME NUMBER 1 Tadamura E, Li W, Prasad PV.

Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nat Med ; [Google Scholar] Löffler R, Ml̈ler CJ, Peller M, et al.

Optimization and evaluation Cited by:   Oxygen enhanced MRI (OE-MRI) is an emerging imaging technique for quantifying the spatial distribution and extent of tumor oxygen delivery in vivo. In OE-MRI, the longitudinal relaxation rate of protons (ΔR 1) changes in proportion to the concentration of molecular oxygen dissolved in plasma or interstitial tissue by: MR imaging has recently played a greater role in examining the morphologic and physiologic characteristics of mouse models of lung disease where structural changes are highly correlated to abnormalities in respiratory function.

The motivation of this work is to develop oxygen-enhanced MR imaging for mice. Stock KW, Chen Q, Morrin M, Hatabu H, Edelman RR () Oxygen-enhanced magnetic resonance ventilation imaging of the human lung at and T. J Magn Reson Imaging Author: Olaf Dietrich. Kruger SJ et al () Oxygen-enhanced 3D radial ultrashort echo time magnetic resonance imaging in the healthy human lung.

NMR Biomed 27(12)– CrossRef Google Scholar Kuo W et al () Monitoring cystic fibrosis lung disease by computed by: 2. During the s and early s, technical limitations of magnetic resonance imaging (MRI) limited its role for visualisation and functional assessment of the lung.

This was due to its low proton density, which results in low signal-to-noise ratio, image degradation by Cited by:. This study demonstrates the specificity of a collagen-targeted magnetic resonance imaging probe to noninvasively identify pulmonary fibrosis in a mouse model of the disease.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown cause that primarily affects older adults.

In the majority of cases, it is a relentlessly progressive disease that results in dyspnea Cited by: Over recent years Magnetic Resonance Imaging has become a well-established textbook on basic MRI technique.

A comprehensive survey of the analytical treatment of MRI physics and engineering, it gives readers the background needed to cope with the problems that arise when applying MRI in medicine or when (sub)systems or sequences for new applications are by: CLINICAL IMAGING - Mini-Review Magnetic Resonance Imaging of the Retina: From Mice to Men Timothy Q.

Duong* This mini-review provides an overview of magnetic resonance imaging (MRI) applications to study rodent, cat, non-human primate, and human retinas. These techniques include T 1- and T 2-weighted anatomical, diffusion, blood flow, blood volume,Cited by: